Weight Rebound | Fat Loss Explained | Why Weight Gain can Happen After a Diet (Fat Cell Science)

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Weight Rebound | Fat Loss Explained | Why Weight Gain can Happen After a Diet (Fat Cell Science) – Thomas DeLauer

A study in the New England Journal of Medicine, hunger-related hormones disrupted by dieting and weight loss can remain at altered levels for at least a year. What this study looked at, however, was whether these changes in hormone levels persist after an individual loses weight – to find out, researchers put 50 overweight or obese men and women on a very low-calorie diet for 10 weeks, then tracked their hormone levels for one year. Blood tests showed that average levels of several hormones (including leptin, ghrelin, and insulin) had changed as a result of the weight loss. As expected, the participants also reported being hungrier – both before and after breakfast – than they had been at the study’s start. At the 10-week mark the participants were allowed to resume a normal diet, but they continued to receive periodic advice from a dietitian and were also encouraged to get 30 minutes of exercise most days of the week. One year later, they’d regained about 12 pounds, on average, and follow-up tests showed that their hormone levels had only partially stabilized – their hunger levels remained elevated as well.


Keto RMR Study:
Study – Long term results on keto- A study published (Feb, 2018) in the journal Nutrition & Metabolism looked to see keto’s effect on permanent weight loss via its effects on RMR. Researchers chose a set of 20 obese patients who followed a low-calorie keto diet in order to induce weight loss (was pretty low calorie; 600-800 kcal) – the subjects lost around 45 lbs each over the course of 4 months. But what they found was that despite the patients’ large weight loss, it didn’t affect the patients’ RMRs in any significant way – there was no significant differences in their basal RMR and no metabolic adaptations occurred.

Study – American Journal of Clinical Nutrition:
Study looked to see if the reduction in energy expenditure persists in persons who have maintained a body-weight reduction of greater than or equal to, 10% for more than 1 year.

Seven trios of subjects were studied and they received a weight-maintaining liquid formula diet of identical composition. Each trio consisted of a subject at usual weight (Wt(initial)), a subject maintaining a weight reduction of greater than or =10% after recent (5-8 week) completion of weight loss (Wt(loss-recent)), and a subject who had maintained a documented reduction in body weight of greater than 10% for more than 1 year (Wt(loss-sustained))

*Sustained weight, recently lost weight, had lost weight and kept it off for over a year*

24-hour total energy expenditure (TEE) was assessed and resting energy expenditure (REE) and the thermic effect of feeding (TEF) were measured as well.

TEE, NREE, and (to a lesser extent) REE were significantly lower in the Wt(loss-sustained) and Wt(loss-recent) groups than in the Wt(initial) group. Differences from the Wt(initial) group in energy expenditure were qualitatively and quantitatively similar after recent and sustained weight loss.

Concluded that:
Declines in energy expenditure favoring the regain of lost weight persist well beyond the period of dynamic weight loss (2)


1) Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653640/
2) Hirsch J and Batchelor B. (n.d.). Adipose tissue cellularity in human obesity. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/1085232
3) The role for adipose tissue in weight regain after weight loss. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371661/
4) Effects of weight gain and weight loss on regional fat distribution. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396439/
5) Resting metabolic rate of obese patients under very low calorie ketogenic diet. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816424/
6) Rosenbaum M , et al. (n.d.). Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18842775/
7) Müller MJ and Bosy-Westphal A. (n.d.). Adaptive thermogenesis with weight loss in humans. – PubMed – NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23404923/
8) Long-Term Persistence of Hormonal Adaptations to Weight Loss | NEJM. (2011, October 26). Retrieved from https://www.nejm.org/doi/full/10.1056/NEJMoa1105816
9) Resting metabolic rate of obese patients under very low calorie ketogenic diet. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816424/
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20 thoughts on “Weight Rebound | Fat Loss Explained | Why Weight Gain can Happen After a Diet (Fat Cell Science)

  1. Im sooooooo…angry ND emotional right now????????……I was 187 went down to 145 n a year….,now I'm 160 8 months later ????????????????????

  2. Hi Thomas!
    I have been fasting for one year now, on may 2020, I started IF, but the hunger went away and I started prolonged fasting, first for 3 days, then 5 days for a month, then 12 days, 12 days and 21 days, lost 30 kilos in 2 1/2 months , after refeed and some days later I gained 7 kilos. I started 2-3 days of fasting for 2 months, i was 143 kilos when I started, and I’m 6’2, I went down to 106 kilos, but I gained weight right away 7 kilos after I went back eating and 5 more in 6 months, even though I did keto and IF almost everyday, some months I go for 5 days or 10 days of prolonged fasting, I have been doing 18 hr IF and lifting weights right before my first meal and I have gain lots of muscle I asume due to the HGH in the 18 hr fast, but 2 months ago I’ve notice that I am gaining weight even though I’m doing 2 days water fast every week and eating around 2000 cal, because my stomach can take any more food, some times I do 1 meal and a bullet proof coffee, because it’s too much food.
    I have done 170 days of water fast in 400 days in total, and taking my electrolytes and teas (ginger, turmeric, green and black teas, etc).
    In this last 2 months I’ve gained 2 inches in my stomach, doing everything right, now I move to eating my 3 meals a day and trying to eat 3000 calories a day to see if I lowered my BMR of too much fasting, I hope I start seeing some results, I think my body is storing everything I eat in my belly as a distribution center.
    Do you have any thoughts ?
    I recently did a 10 day water fast and only lost 1.5 kilos after refeeding, that’s why I am concern ! And some weeks not eating for 2 days and gaining weight in those weeks!
    Hope you can read this post and give me your feedback, thanks
    I have lost my weight by using your info in your videos , thnx for sharing your knowledge ???????? !!! I’m very greatfull !!!

  3. Lost 68lbs in 6 months as of last saturday. I was 205lbs. 4 days later as of this morning, I'm 229lbs. I took a 4 day break and gained 24lbs. Mostly water weight, but damn…

  4. I lost 20 pounds recently and then everything was good. I’d eat and workout and won’t put on weight whatsoever. Then suddenly within a couple days I gained 10 pounds. I’m working out and eating clean but I’m am unable to reduce weight again. CAN SMONE ADVISE ME?

  5. I don’t understand though. I walk 2 hours a day, maintain a low sugar, low sodium, low carb and low saturated fat diet. I eat mainly fruit, veg and white protein (about 1200 kcals a day) but I still gained back the 3kgs I lost! Can someone please enlighten me? ????‍♀️

  6. I was very thin, lean, a runner. I went to Texas for 4 days and….you already know. Now Im starting over -_-….

  7. I was able to loose weight with the natural herbs medicine product which i order from doctor Ehimare on YouTube. God bless you doctor Ehimare on YouTube channel????.

  8. So what's the solution if we haven't lost weight throug Keto to evoid rebound ? we cant' go back in time and do keto unfortunately

  9. My body feels like its in a "reverse keto" ?
    I've regained the 5 stone I'd lost last year and balooned !! Despite trying to eat Low carb…havn't touched a slice of bread,an apple or a carrot (too many carbs) my fat cells have definitely grown ,multiplied…
    My execersise has gone to Zilch because of a painful spinal ,complicated twisted crushed discs…
    How on Earth can I get back on track ??
    Help !!!

  10. So… moral of the story…. Don’t eat or you’ll get even fatter than you’ve ever been. You may explode!

  11. I used to be so into weight loss i did fasting, keto and liss sometimes hiit. Then life happened. Got into drinking and a bad breakup and put on 100 pounds. It sucks because it almost like the two years i put in to lose weight is gone in a matter of weeks. Im on my way back but this time i want to sustain a healthy lifestyle. I used to do crazy amount of cardio, i just dont have that time anymore now that i invest and go to school. Im far more wealtheir/succesful but now i just want to be fit. i felt like a million bucks back then when i was poor but fit.

  12. I’ve been a participant in this Keto/fasting space for a while, but this is THE light-bulb video that’s explained the science-behaviour relationship in a way that’s clicked for me. I knew there was a reason I liked you, DeLauer.

  13. How much does stress influence the yoyo effect or weight gain while on keto? I have been on keto for about 3 years and dropped from 230 to 175 and then my weight went up to 190 and I can't seem to get it to drop.

  14. what if used to eat 500 cals per day and now I've been eating 900-1400 cals per day and I am still gaining weight?

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